Debbie discusses balancing the need to encourage victims of sexual assault to come forward while protecting due process for the accused. The U. The Manual, which takes effect today, will govern how OCR investigates and resolves discrimination complaints going forward. We are often asked: What are the courts doing in student respondent litigation? What steps can we take to lessen our risks in this area?
A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2
The disorder has no therapy and there are no models to test new treatments. These animals and cells derived from them showed protein glycosylation deficiencies similar to those found in patients with PMM2-CDG. These imbalances, resulting from defective glycosylation, are likely the cause of the stunted growth seen both in our model and in PMM2-CDG patients. Over-expression of WT-PMM2 in patient-derived fibroblasts rescued all these defects, showing that restoration of mutant PMM2 activity is a viable therapeutic strategy. This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease. Congenital disorders of glycosylation CDG are rare genetic diseases in which glycosylation pathways are defective 1.
Zotero Mendeley EndNote. A note on the changing relationship between fertility and female employment rates in developed countries. Journal of Population Economics, 15 4 , Bassin, D. Representations of motherhood.
Mark Jerrold Henry  born June 12,  is an American powerlifter , Olympic weightlifter , strongman , and retired professional wrestler , who is currently signed to WWE under a Legends contract. He also works backstage as a producer. National Champion  and  as well as an all-time raw world record holder in the squat and deadlift. He is credited for the biggest raw squat and raw powerlifting total ever performed by a drug tested athlete, regardless of weight class,  as well as the greatest raw deadlift by an American citizen.